I agree that Kathryn obviously had no more use for Regina and it is possible she is dead. I however, want to believe that she is still alive somehow, and so for the moment am hoping for the FTL heart removal, but still alive in SB. If it is Kathryn’s heart taken in FTL, then it is possible Kathryn is still alive, because the heart is whole. Regina crushed Graham’s heart in order to kill him. So, there is hope given that consideration.