I think one of the spots is almost certainly spoken for by Snow and Charming’s baby, who would be Emma’s sibling and Henry’s new aunt or uncle. Another possibility is that Rumple will finally marry Belle, officially making her part of Henry’s family tree as his step-grandmother and Neal’s step-mother.
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"That’s how you know you’ve really got a home. When you leave it, there’s this feeling that you can’t shake. You just miss it." Neal Cassidy