“When we learn more about the wicked witch and her backstory, we’ll understand that what she has against Regina is a… global problem,” Kitsis reveals.
I think that Zelena is angry at Regina, and this new curse has far-reaching implications, on a “global” scale. Possibly the worlds are now “bleeding through” which could explain the title for 3×18.
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"That’s how you know you’ve really got a home. When you leave it, there’s this feeling that you can’t shake. You just miss it." Neal Cassidy