Re: Could Regina and Jefferson be siblings? Home › Forums › Once Upon a Time › General discussion and theories › Could Regina and Jefferson be siblings? › Re: Could Regina and Jefferson be siblings? June 9, 2012 at 5:30 pm #148524 theladybelleParticipant I also don’t think it’s likely that they are siblings, if I have to be honest. It would be a little… odd if they actually were. I still like the idea, and I wouldn’t mind it if they actually were siblings. [adrotate group="5"]