Re: Could Regina and Jefferson be siblings? Home › Forums › Once Upon a Time › General discussion and theories › Could Regina and Jefferson be siblings? › Re: Could Regina and Jefferson be siblings? June 10, 2012 at 1:19 am #148535 hjbauParticipant It would seem bizarre to me that Regina would tell anyone they could call her by her first name unless they were family. Or arch nemesis like Snow. Or another ruler like King George. [adrotate group="5"]