So, if Regina knew (for sometime) that Emma was Snow’s daughter, then she also knew that Henry is Snow’s grandson. I would have liked to have seen Regina’s face the moment she realized that her adopted son was Snow’s grandson. That would have been a great moment. Maybe we will see that moment (flashback) in season two.
I don’t think that connection matters that much to Regina because she still loves Henry regardless. She wasn’t like ‘Eww! I adopted Snow White’s grandson!” Sort of like, ‘Ew! You have cooties!” 😆 😆