Didn’t Regina say to Rumple about not using to much magic or she will turn green or something like that so I am still on board with the Sister thing nor the green apple.
Yes, Regina did say something about turning green in 2×2.
I’m pretty sure she was just speaking figuratively though. BUT it was a deliberate popular reference/hint towards Oz.
The green apple is just an interesting theory that this point, since Regina loves her apples. It’d be too juicy an opportunity to pass up. Get it? Juicy? LOL
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"That’s how you know you’ve really got a home. When you leave it, there’s this feeling that you can’t shake. You just miss it." Neal Cassidy