Regina is fond of mirrors, so they could tie her into the Medusa story through that plot point. If they wanna stick with the actual t-word of myth though, Medusa shouldn’t be alive in Snowing’s time, because when Medusa died, she gave birth to Pegasus, and in the Onceiverse, Pegasus lived about 300 years previously, because the Jones brothers had its feathers for the sail.
One word: Midas.
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"He was a lot of things to me" "The only conclusion was love"