Or has it already been opened once, released its evil and is now free to trap Pan?
I mentioned this in spoilery talk before the ep aired, but my current crackpot theory is that Blue was Pandora, who opened the box long ago and let all the evil out, and now Rumple’s gonna use it to trap Pan.
In the previous ep, when Regina was saying that maybe there was a way other than killing Pan, she actually said, “something to contain him” which is when Rumple got the idea of using the Box.