I don’t think RQ is Grace’s mother. Jefferson said he lost Grace’s mother because of his work so perhaps RQ killed her or did something to her.
Ah but what does “lost” mean. It’s like “undoing.” Lost can mean death but it could also mean that Jefferson lost the woman he loved if she became cruel and evil and altogether a different person. Is Regina still the same Regina Daniel loved after what she did to Snow or would he consider her “lost” too?
Something to ponder.
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"He was a lot of things to me" "The only conclusion was love"